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Updated: Jun 11, 2025

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单链针环RNAs (loopmeRNAs) 通过RNA干扰途径强烈诱导基因沉默

Krishna C Aluri1, Dhrubajyoti Datta1, Scott Waldron1

  • 1Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts 02142, United States.

Journal of the American Chemical Society
|October 7, 2024
PubMed
概括

新的循环毛RNAs (loopmeRNAs) 提供了一种更简单的方法来制造强效的肝病药物. 这些单链RNA分子包含稳定性和有效性的化学修饰,类似于传统的siRNAs,但负担较小.

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