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Updated: Jun 11, 2025

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甲状腺激素类似的GC-1通过抑制M1巨细胞极化来缓解急性肺损伤

Bin Li1,2, Cong Xia1, Wanyu He1

  • 1Pingyuan Laboratory, State Key Laboratory of Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Organ Fibrosis, College of Life Science, Henan Normal University, Xinxiang, 453007, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|October 7, 2024
PubMed
概括

在急性肺损伤 (ALI) 模型中,甲状腺激素模拟GC-1可减少炎症和肺损伤. 它通过TRβ1-依赖的DNMT3b-PPARγ-NF-κB通路抑制M1巨细胞极化而起作用,提供了一个新的抗炎症策略.

关键词:
阿里/阿尔德斯 (ALI/ARDS) 是一个在DNMT3b-PPARγ-NF-κB路径中.在 GC-1-1 中.巨细胞的两极分化甲状腺激素是甲状腺激素的一种.

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