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Updated: Jun 11, 2025

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models
10:04

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

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在患有KEAP1突变和家族非毒性多种结节的患者中,结节特异的NRF2-向升调

Eijun Nishihara1, Shuji Fukata1, Mitsuyoshi Hirokawa1

  • 1Center for Excellence in Thyroid Care, Kuma Hospital, Kobe 650-0011, Japan.

The Journal of clinical endocrinology and metabolism
|October 7, 2024
PubMed
概括

凯尔克类ECH相关蛋白1 (KEAP1) 突变通过增加核因素2 (NRF2) 相关因子2 (NRF2) 活性,导致家族多节. 这导致甲状腺激增,具有细胞保护作用和缓慢增殖.

关键词:
KEAP1生殖系突变发生在KEAP1生殖系中针对NRF2的基因是目标基因.这是一种家族性羊肉.多模块囊 (Multinodular Goiter) 是一种多模块囊.

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