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Updated: Jun 11, 2025

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PhageDive:是关于 prokaryotic 病毒多样性的综合性菌株数据库

Clara Rolland¹, Johannes Wittmann¹, Lorenz C Reimer¹

¹Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH, 38124 Braunschweig, Germany.

Nucleic acids research

|October 7, 2024

概括

PhageDive是一个新的数据库,将来自不同来源的原生细胞病毒数据整合起来. 该资源增强了对菌体信息的获取,促进了比较基因组分析和研究整合.

科学领域:

微生物学微生物学
生物信息学是一种生物信息学.
病毒学病毒学

背景情况:

Prokaryotic 病毒 (细菌体) 是地球上最丰富的生物实体.
现有的菌体数据是碎片化的,非标准化的,很难与基因组信息联系起来.
这阻碍了对比分析和全面研究.

研究的目的:

开发PhageDive,一个中央集中的,全面的数据库,用于原生细胞病毒数据.
标准化和整合分散的菌体信息,以便更容易访问和分析.
将实验数据,基因组数据和物理生物资源联系起来.

主要方法:

来自科学出版物,专业数据库和文化收藏的汇总数据.
开发了一个数据库,其中包含实验数据 (宿主范围,基因组学) 和元数据 (来源,源) 的字段.
来自DSMZ,Félix d'Hérelle参考中心和NCTC的综合数据,涵盖了1167种菌体.

主要成果:

PhageDive提供了一个统一的平台,用于原生生物病毒数据.
该数据库将实验数据与培养收集号码和生物资源存储库联系起来.
具有先进的搜索功能,使用受控的词汇库和对分类学和形态学的本体学.

结论:

体潜水器 (PhageDive) 便于整合菌体研究数据.
该数据库增强了与NCBI和VHRdb等其他资源的互操作性.
PhageDive支持比较分析,并推动了对 prokaryotic 病毒的研究.

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