Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jun 11, 2025

Laboratory-Engineered Glioblastoma Organoid Culture and Drug Screening
10:49

Laboratory-Engineered Glioblastoma Organoid Culture and Drug Screening

Published on: January 10, 2025

539

质母细胞瘤皮质器官 总结 细胞状态异质性和细胞间转移

Vamsi Mangena1,2, Rony Chanoch-Myers3, Rafaela Sartore2,4

  • 1Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

Cancer discovery
|October 7, 2024
PubMed
概括

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.

Nature genetics·2026
Same author

Acquired genetic and cell-state changes in IDH-mutant glioma progression.

Nature·2026
Same author

Disordered protein LAT encodes relative levels of signaling pathways in T cell activation.

Science (New York, N.Y.)·2026
Same author

Experimental and computational methods for allelic imbalance analysis from single-nucleus RNA-seq data.

Genome biology·2026
Same author

Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability.

Nature communications·2026
Same author

A blueprint for local and distal invasion programs in glioblastoma.

Nature communications·2026

质母细胞瘤 (GBM) 器官体揭示了从瘤细胞到健康的大脑细胞的遗传物质的广泛转移. 这种由细胞外囊泡介导的细胞间传输,为GBM微环境提供了新的见解.

科学领域:

  • 神经瘤学神经瘤学
  • 癌症生物学 癌症生物学
  • 有机体模型模型

背景情况:

  • 质母细胞瘤 (GBM) 是一种复杂的大脑瘤,其异质细胞集成到神经质微环境中.
  • 像质球这样的现有模型不能完全捕捉到GBM内部复杂的细胞相互作用.

研究的目的:

  • 开发和使用长期的人类皮质器官来建模GBM生态系统.
  • 研究GBM神经质微环境中的细胞间通信和转录传输.

主要方法:

  • 在人类皮质器官体内培养患者衍生的质母细胞瘤 (GBM).
  • 使用单细胞RNA测序来分析细胞多样性和基因表达.
  • 使用GFP标记的GBM细胞来跟踪转录和物质转移.

主要成果:

  • 与质球相比,GBM皮质器官更准确地反映了患者瘤细胞的多样性和表达.
  • 观察到 Glioblastoma (GBM) 转录和 GFP 从恶性细胞广泛转移到非恶性细胞.
  • 细胞外囊泡调解这种转移,显示偏向特定的质母细胞瘤 (GBM) 细胞状态和星.

结论:

  • GBM皮质有机体为研究质母细胞瘤细胞间动力学提供了一个更忠实的模型.

更多相关视频

Maintaining Human Glioblastoma Cellular Diversity Ex vivo using Three-Dimensional Organoid Culture
07:11

Maintaining Human Glioblastoma Cellular Diversity Ex vivo using Three-Dimensional Organoid Culture

Published on: August 25, 2022

3.2K
Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma
05:45

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Published on: January 19, 2024

1.8K

相关实验视频

Last Updated: Jun 11, 2025

Laboratory-Engineered Glioblastoma Organoid Culture and Drug Screening
10:49

Laboratory-Engineered Glioblastoma Organoid Culture and Drug Screening

Published on: January 10, 2025

539
Maintaining Human Glioblastoma Cellular Diversity Ex vivo using Three-Dimensional Organoid Culture
07:11

Maintaining Human Glioblastoma Cellular Diversity Ex vivo using Three-Dimensional Organoid Culture

Published on: August 25, 2022

3.2K
Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma
05:45

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Published on: January 19, 2024

1.8K
  • 通过细胞外囊泡进行细胞间遗传物质的转移是 Glioblastoma 微环境的一个重要特征.
  • 这种转移机制可能在重编程瘤微环境中发挥作用,并可能与其他癌症类型相关.