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Zhihong Wang¹, Zhuangzhuang Shi², Xiaochen Liao³

¹State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|October 7, 2024

概括

需要新的纳米体策略来对抗像SARS-CoV-2这样快速变异的病毒. 一个三价纳米体,B11-E8-F3,显示了针对SARS-CoV-1和SARS-CoV-2变体的宽频中和,为预防和治疗提供了潜力.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
生物技术是生物技术.

背景情况:

SARS-CoV-2 Omicron亚系表现出显著的免疫逃脱现有的中和抗体.
目前的抗体查方法对快速变异的冠状病毒是不够的.
对于对多种SARS-CoV菌株有效的宽谱中和抗体有着至关重要的需求.

研究的目的:

开发一个全面的策略来设计针对SARS-CoV-1和SARS-CoV-2的宽频中和纳米体.
为了创建新的纳米体库,针对保存的病毒表位.
设计多价值纳米体,以提高中和效率.

主要方法:

一个全人类纳米体图书馆的新设计.
驼免疫能产生一个纳米体库.
通过将多个纳米体连接在一起,以非重叠的表位为目标,构建三价纳米体.
在体外中和化试验和体内动物模型研究.

主要成果:

一种三价纳米体,B11-E8-F3,对SARS-CoV-1和各种SARS-CoV-2变体表现出广泛的中和活性.
在感染真实SARS相关病毒的动物模型中,B11-E8-F3表现出强大的预防和治疗效果.
设计的纳米体有效地准了保存的表观体,提高了它们的广泛适用性.

结论:

三价纳米体B11-E8-F3代表了广泛预防和治疗SARS-CoV-1和SARS-CoV-2感染的有希望的候选人.
这种方法为开发有效的抗体疗法提供了可行的策略,特别是在高风险人群中.
针对保存的表观体的纳米体工程是对抗快速演变的病毒的强大工具.

关键词:

在SARS-CoV-1中.在SARS-CoV-2中.抗体工程是针对抗体的工程.这是一个de novo设计.多价值纳米体是多价值的纳米体.纳米体是一个纳米体.

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