在美国癌症幸存者中,他类药物的使用与死亡结果之间的关联:全国性的队列研究
Shan Ding1, Fengling Yang2, Pan Lai3
1Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, China.
Aging clinical and experimental research
|October 7, 2024
概括
脂性他类药物的使用显著降低了老年癌症幸存者的死亡风险. 这两种类型的他类药物都可能降低癌症特异性死亡率,这表明有针对性的干预措施的潜力.
科学领域:
- 老年学是一门学科.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 美国老年癌症幸存者人口超过1690万.
- 关于癌症幸存者使用他类药物和生存率的研究有限.
研究的目的:
- 调查他类药物使用与癌症幸存者老化中的死亡原因之间的关联.
- 为了区分水友性与脂友性他类药物对生存结果的影响.
主要方法:
- 对来自2968名参与者的NHANES数据 (1999-2018) 的分析.
- 根据处方记录,根据类型分类 (水友性/脂友性) 来得出的他类药物的使用情况.
- 考克斯比例危险模型用于评估与他类药物使用相关的死亡风险.
主要成果:
- 脂友性他类药物使用者 (982) 与非使用者 (1,738) 相比,所有原因死亡率显著降低 (aHR=0.77,P=0.003).
- 水友性他类药物使用者 (216) 没有显示出任何原因死亡率显著降低 (aHR=1.01,P=0.960).
- 两种类型的他类药物都与癌症特异性死亡率的降低有关,其中水友性他类药物显示出更高的疗效.
结论:
- 脂友性他类药物的使用与老年癌症幸存者的全因和癌症特异性死亡率降低有关.
- 类药物显示出降低癌症相关死亡率的潜力,为临床干预提供了信息.
- 进一步的研究可能会探索癌症幸存者的特定机制和最佳他类药物选择.
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