相关实验视频

Updated: Jun 11, 2025

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Published on: March 17, 2023

瘤免疫监测中的线粒体和瘤治疗中向线粒体的瘤治疗

Lvyuan Li^1,2, Yi Zhang^1,2, Qiling Tang^1,2

¹NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China.

Cellular oncology (Dordrecht, Netherlands)

|October 7, 2024

概括

线粒体是细胞能量和新陈代谢的关键调节者,显著影响瘤免疫反应. 本综述探讨了它们在免疫监测和新型线粒体向癌症治疗中的作用.

科学领域:

细胞生物学细胞生物学
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

线粒体是细胞能量生产和代谢调节的核心.
线粒体功能是瘤免疫监测的关键决定因素.
了解线粒体在免疫系统中的作用对于癌症研究至关重要.

研究的目的:

为提供线粒体在瘤免疫监测中的作用的全面概述.
详细说明线粒体如何影响瘤内的先天性和适应性免疫反应.
为突出针对线粒体的新型药物干预,用于癌症治疗.

主要方法:

关于线粒体研究和癌症免疫学的最新进展的文献综述.
对研究线粒体对免疫细胞行为影响的研究进行分析.
探索针对线粒体的新兴治疗策略.

主要成果:

线粒体显著调节免疫细胞功能,影响瘤的发展和进展.
线粒体动力学和信号通路在抗瘤免疫中至关重要.
针对线粒体的新型小分子在临床前癌症模型中表现有前途.

结论:

线粒体对于塑造瘤微环境和免疫反应至关重要.
准线粒体功能为创新的癌症治疗提供了一个有希望的途径.
对线粒体-免疫相互作用的进一步研究可能会提高癌症治疗的疗效.

关键词:

适应性免疫反应是一种适应性免疫反应.免疫监视系统的监视天生的免疫反应.线粒体中的线粒体.瘤治疗疗法瘤治疗

更多相关视频

Analytical Determination of Mitochondrial Function of Excised Solid Tumor Homogenates

Analytical Determination of Mitochondrial Function of Excised Solid Tumor Homogenates

Published on: August 6, 2021

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

相关概念视频

Electron Transport Chain: Complex I and II

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

Mitochondria

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...