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针对成人发病的基于DNA的人口查的负结果:接受者的经验

Felicia Russo^1,2, Debanjana Chatterjee¹, Natalia DeMaria¹

¹Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.

Journal of community genetics

|October 7, 2024

概括

返回负遗传查结果需要明确的沟通. 提供教育材料,如图片,提高了参与者对理解其结果及其影响的信心.

科学领域:

基因组学就是基因组学.
个性化医疗是个性化的医疗.
公共卫生公共卫生

背景情况:

基于DNA的人口查成人发病正在推进个性化医学.
对公共卫生计划来说,负面结果的有效返回是至关重要的.
了解参与者对负面遗传结果的理解至关重要.

研究的目的:

探索成年人的经历,从基于DNA的查的负面结果.
评估补充教育材料对结果理解的影响.
识别潜在的误解及其对未来遗传测试的影响.

主要方法:

调查了一组437名从eMERGE-3项目中获得负面结果的成年人.
参与者被随机分配,接受或不接受说明片.
调查评估了动机,结果理解和解释结果的信心.

主要成果:

许多参与者的动机与查目标不一致,寻求诊断或家庭风险信息.
四分之一的参与者对解释他们的负面结果缺乏信心.
收到图片的受试者对理解结果的信心更高 (19%对29%缺乏信心).

结论:

返回负遗传查结果是复杂的,需要明确的沟通策略.
像小幅画这样的教育材料可以提高参与者的理解和信心.
误解负面结果可能会导致个人放弃适当的基因测试,需要进一步研究有效的沟通方法.

关键词:

信息传播信息传播信息传播了解理解理解理解理解理解基于DNA的人口查.教育教育教育教育教育教育.有负面结果的结果.

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