长度变化表观遗传年龄加速在整个童年和青春期
Juan Del Toro1, Connor Martz2, Colin D Freilich1
1Department of Psychology, University of Minnesota-Twin Cities, Minneapolis.
JAMA pediatrics
|October 7, 2024
概括
种族歧视加快了黑人和西班牙裔年轻人的表观遗传衰老,警察遭遇加剧了这种影响. 白人年轻人经历的衰老速度不那么快,突出了青春期健康结果的差异.
科学领域:
- 表观遗传学和发育生物学
- 公共卫生和社会流行病学.
- 种族正义和健康平等.
背景情况:
- 歧视可能加速表观遗传衰老 (细胞衰老指标).
- 表观遗传衰老的纵向变化及其在不同青年群体中的异质性仍然未得到充分研究.
- 诸如歧视之类的上下文因素可能解释了老龄化的种族/民族差异.
研究的目的:
- 在多样化的青年样本中描述从童年到青春期表观遗传年龄加速的变化.
- 检查跨种族和种族群体表观遗传衰老的变异.
- 调查警察入侵与表观遗传衰老差异之间的关联.
主要方法:
- 纵向队列研究使用来自"家庭的未来和儿童福祉研究"的数据.
- 包括2039名年轻人在9岁和15岁时具有唾液DNA甲基化数据.
- 通过使用Hannum,GrimAge,PhenoAge和DunedinPACE时钟分析了表观遗传年龄加速.
主要成果:
- 白人年轻人比黑人,西班牙裔和其他9至15岁的种族/民族群体表现出不那么加速的表观遗传衰老.
- 警方的入侵与黑人青年在多个表观遗传时钟中更快的表观遗传衰老有关.
- 在Hannum,GrimAge,PhenoAge和DunedinPACE时钟中观察到显著的关联.
结论:
- 青春期是种族主义可能对长期健康产生负面影响的关键时期.
- 调查结果强调需要解决社会政策和影响少数群体青少年的系统歧视问题.
- 需要进一步的研究,以确定延续这些健康差异的特定社会因素.
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