化学抗原受体T细胞治疗高级血液恶性新生体后的心血管事件:元分析
David Koeckerling1,2, Rohin K Reddy3,4, Joseph Barker3
1Department of Cardiology, Angiology and Respiratory Medicine, University Hospital Heidelberg, Heidelberg, Germany.
JAMA network open
|October 7, 2024
概括
图形抗原受体 (CAR) T 细胞治疗中的心脏毒性尚不清楚. 这一元分析发现心室心律不整和心肌梗塞的发病率较低,但左心室功能障碍和脑上心律不整的发病率较高.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 化学抗原受体 (CAR) T细胞疗法的心脏毒性尚不清楚,因为临床试验经常排除高风险心血管患者.
- 关于CAR T细胞接受者心血管并发症的现实数据有限.
研究的目的:
- 为了确定接受CAR T细胞治疗高级血液恶性瘤的成年患者中不良心血管事件的患病率.
主要方法:
- 在主要数据库 (MEDLINE,Embase,Cochrane Library,Google Scholar) 进行了系统的文献搜索,直到2024年2月.
- 包括成年CAR T细胞接受者有先进的血液恶性瘤的观察性研究,报告了心血管并发症.
- 使用随机效应模型对单个比例进行了元分析,以计算聚合的流行率估计.
主要成果:
- 分析了13项涉及1528名患者的研究. 综合的患病率包括:心室节律失常 (0.66%),脑上心室节律失常 (7.79%),左心室功能障碍 (8.68%),心力衰竭 (3.87%),心肌梗塞 (0.62%) 和心血管死亡 (0.63%).
- 所有原因的死亡率为30.01%.
- 敏感性分析证实了这些发现.
结论:
- 在短期至中期随访中,CAR T细胞治疗与心室节律失常,心肌梗塞和心血管死亡的低患病率有关.
- 左心室功能障碍和心室上心律不整是最常见的心血管并发症.
- 心血管监测应优先监测喷射分数和心室上心律不整.
更多相关视频
06:08Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
1.3K
06:51Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
Published on: December 17, 2019
14.9K
相关概念视频
01:21Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
01:27Tumor Immunotherapy
489
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
489