弥合差距:神经发育障碍风险在先天免疫错误中的风险
Devika Kurup1, Amy M FitzPatrick, Aleksandra Badura
1Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
Current opinion in allergy and clinical immunology
|October 7, 2024
概括
免疫的先天性错误 (IEI) 越来越多地与神经发育障碍 (NDD) 相关. 本次审查强调了对这些并发病的临床医生更大认识和及时干预的需要.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
背景情况:
- 免疫的先天性错误 (IEI) 是一组影响免疫系统的多种遗传疾病.
- 在IEI患者中,越来越多地发现非免疫性并发症,包括神经疾病.
- 与其他神经症状相比,神经发育障碍 (NDD) 与IEI相关的描述较少.
研究的目的:
- 审查IEI患者神经发育表型的已发表文献.
- 在IEI的背景下,探索免疫系统和中枢神经系统之间的相互作用.
- 讨论免疫-中枢神经系统相互作用对临床管理的影响.
主要方法:
- 系统审查IEI发表的临床报告和病例描述.
- 对被诊断患有IEI的患者中记录的神经发育结果的分析.
- 在IEI队列中搜索报告共患NDD的研究的文献.
主要成果:
- 越来越多的报告表明IEI和NDD之间存在共患.
- 确定的特定NDD包括自闭症谱系障碍 (ASD),智力障碍和行为缺陷.
- 在IEI中NDD的患病率仍然未知,这表明潜在的诊断不足.
结论:
- IEI患者表现出一系列的NDD,这些NDD往往是未被充分认识到的.
- 对IEI中NDD的早期识别和干预对于改善生活质量和减少医疗负担至关重要.
- 对IEI中免疫-中枢神经系统相互作用背后的病理机制的进一步研究是有必要的,以指导临床实践.
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