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利用光谱光度学分辨率功率来确定三元混合物用于其制药配方中的呼吸系统疾病治疗

Huda Salem AlSalem¹, Faisal K Algethami², Maimana A Magdy³

¹Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

|October 7, 2024

概括

开发了两种光谱光度测量方法,用于量化HYX,EPH和THP在呼吸系统疾病治疗中的含量. 这些环保方法可以准确分析制药配方中的三元混合物.

科学领域:

分析化学分析化学
频谱光度测量 (Spectrophotometry) 是一种光谱光度测量技术.
药品分析药品分析

背景情况:

呼吸道疾病通常用组合疗法治疗.
在多组分配方中精确量化活性药物成分 (API) 对患者安全和治疗疗效至关重要.
现有的分析方法可能缺乏常规药物分析的效率或环境可持续性.

研究的目的:

开发和验证两种新型光谱测量方法,用于同时确定氧化 (HYX),乙烯 (EPH) 和神 (THP).
评估开发的分析方法的环保性和适用性.
将拟议方法的性能与现有技术 (如高性能液态染色学 (HPLC)) 进行比较.

主要方法:

方法A:利用比减法与衍生光谱测量 (3D) 结合用于THP,HYX和EPH的顺序确定.
方法B:采用多变量校准技术,包括主要成分回归 (PCR) 和部分最小平方 (PLS),使用210-230nm区域的光谱数据.
使用合成混合物,制药制剂的验证方法,并使用GAPI,AGREE和BAGI指数评估绿色.

主要成果:

这两种光谱法都成功地解决并量化了HYX,EPH和THP的三元混合物,而无助剂的干扰.
方法A允许直接确定THP和HYX,然后对EPH进行3D光谱光度测量.
方法B (PCR和PLS) 通过交叉验证和外部验证证明了有效的量化和良好的统计验证.
绿色分析评估表明这些方法的环保性和可持续性.
开发的方法显示了与HPLC可比的结果,并且被发现对制药分析具有实用性.

结论:

拟议的光谱法 (减比/导数和多变量校准) 准确,精确和高效,用于分析HYX,EPH和THP的三元混合物.
这些方法适用于含有这些API的制药配方的质量控制.
该研究强调了与绿色化学原则一致的环保分析程序的发展.

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Spectrophotometry: Introduction

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