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Updated: Jun 11, 2025

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene
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通过MAD1的上调调节,使其对炎症介导的瘤形成敏感

Sarah E Copeland1, Santina M Snow2,3,4, Jun Wan5

  • 1Molecular and Cellular Pharmacology Graduate Training Program, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

PLoS genetics
|October 7, 2024
PubMed
概括

过度表达的线索性停滞缺陷1 (MAD1L1) 在小鼠中促进了结肠癌的发展. 这种上调导致染色体不稳定和瘤形成,特别是在男性中,突出MAD1L1

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