我如何在急性髓性白血病中使用维持疗法
Gail J Roboz1,2, Jonathan Canaani1,2
1Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY.
Blood
|October 7, 2024
概括
在初始治疗后,在急性髓性白血病 (AML) 中维持缓解是具有挑战性的. 本综述讨论了针对AML患者的个性化缓解后维持策略,以减少复发风险.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床治疗学 临床治疗学
背景情况:
- 由于新型治疗方法,扩大干细胞移植 (SCT) 接入,以及提高SCT安全性,急性髓性白血病 (AML) 的结果有所改善.
- 虽然最初的缓解是常见的,但长期缓解和AML的复发预防仍然是重大的临床挑战.
- 放出后维护策略已经显示出不同的成功,并且最近才被纳入标准的AML护理中.
研究的目的:
- 提出四种临床情景,说明急性髓性白血病 (AML) 缓解期患者管理的挑战.
- 讨论目前在AML治疗中缓解后维持治疗的方法.
- 强调选择AML维护策略的个性化性质.
主要方法:
- 关于急性髓性白血病 (AML) 维持疗法的已发表研究和新出现的临床数据的审查.
- 讨论AML治疗后治疗的临床决策.
- 分析影响选用AML维护策略的因素.
主要成果:
- 选择AML维持疗法是复杂的,需要仔细考虑多个患者特异性的因素.
- 没有一种单一的维持方法对所有缓解的急性髓性白血病患者来说是普遍最佳的.
- 新出现的数据支持整合量身定制的维护策略,以改善长期的反洗钱结果.
结论:
- 个性化后释放维护对于优化急性髓性白血病 (AML) 的长期结果至关重要.
- 治疗决策必须整合白血病生物学,风险分层,突变状态,先前治疗和患者因素.
- 需要进一步的研究和临床数据来完善和个性化AML维护策略.
相关概念视频
Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Cancer Stem Cells and Tumor Maintenance
4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
Bone Marrow Sampling and Transplants
313
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
313
Myocarditis IV: Nursing Management
2
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
2
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K


