对生物打印心脏贴片的进步和挑战进行批判性审查
Xiaoqing Zhang1, Guangtao Zhao2, Tianyi Ma3
1School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003, China; Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, University of Toronto, Toronto, Ontario M5G 1M1, Canada.
Acta biomaterialia
|October 7, 2024
概括
本综述探讨了用于心肌修复的心脏贴片生物打印的创新,重点关注生物材料,生长因子和调节. 它解决了细胞生成,血管化和用于心脏修复的临床翻译方面的挑战.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 组织工程是组织工程.
背景情况:
- 心肌梗塞 (MI) 影响全球0.25亿人,导致不可逆转的心肌死.
- 生物打印技术的进步现在专注于控制细胞微环境以进行组织再生.
- 心脏贴片生物打印是管理修复心肌组织的关键领域.
研究的目的:
- 批判性地审查心脏贴片生物打印中最近的生物医学创新.
- 评估生物材料设计,生长因子,生物机械/生物电气调节和4D生物打印策略.
- 讨论生物打印心肌贴片临床翻译的挑战和监管问题.
主要方法:
- 对心脏贴片生物打印中的最近生物医学创新进行了审查.
- 考虑生物材料设计,生长因子,调节和4D生物打印.
- 分析细胞生产,血管化,仿生和精密生物打印方面的挑战.
主要成果:
- 在管理心脏组织修复的微环境方面取得了重大进展.
- 确定包括细胞数量,血管网络密度和生物材料ECM相似性在内的关键挑战.
- 讨论临床翻译障碍,监管问题以及跨学科合作的必要性.
结论:
- 心脏贴片生物打印需要整合生物材料设计,制造和后制造过程.
- 解决临床可行性和监管问题对于生物墨水和工艺设计至关重要.
- 机器人,自动化和人工智能可以提高心脏贴片的生产力,标准化和商业化.
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