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在不同出生体重的新生儿的腹沃顿果中的miRNAs:试点研究

Cristina García-Muro¹, Cristina Toledo-Gotor², Sara Pasamón-García¹

¹Department of Pediatrics, Hospital San Pedro, Logroño, Spain.

|October 7, 2024

概括

带组织中的微RNA (miRNA) 表达与出生体重有关. 对于妊娠年龄 (SGA) 新生儿的低调 miR-324-3p 表明SGA在SGA发育中的作用.

科学领域:

围产儿医学围产儿医学
分子生物学分子生物学
遗传学遗传学是一种遗传学.

背景情况:

出生的体重是围产期健康的关键指标.
微RNA (miRNA) 是小型非编码RNA,可以调节基因表达.
miRNA失调与胎儿生长和出生体重变化有关.

研究的目的:

从带组织中分离和分析miRNA表达.
为了比较妊娠年龄小 (SGA),妊娠年龄大 (LGA) 和妊娠年龄适合 (AGA) 新生儿的miRNA概况.

主要方法:

从23个带组织样本 (8个SGA,10个LGA,5个AGA) 中进行miRNA表达特征的高通量测序.
生物信息分析以评估差异性miRNA表达.
样本是在分娩后立即采集的.

主要成果:

在6种miRNA中发现了显著的表达差异.
在SGA与AGA和LGA之间,miR-324-3p的调控下降.
在LGA与SGA和AGA之间,miR-337-3p被调高;在LGA与SGA和AGA之间,miR-760被调低.
miR-4707-3p,miR-548a-3p,miR-6733-5p在SGA和LGA与AGA中的上调调.
大多数已识别的miRNA与转化生长因子-β信号通路有关.

结论:

带组织的miRNA表达与出生体重有关.
在SGA新生儿中,miR-324-3p的下调可能是导致SGA的因素.
这项研究突出了出生体重评估的潜在miRNA生物标志物.

关键词:

出生的体重出生时的体重.怀孕年龄怀孕年龄增长的增长增长的增长新生儿是一种新生儿.这就是miRNAs.

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...