鼓舞性肌肉训练可以改善肌痛性脑筋炎/慢性疲劳综合征和SARS-CoV-2的急性后续症状中的自主功能:试点研究
Heather Edgell1, Tania J Pereira2, Kathleen Kerr3
1School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada; Muscle Health Research Centre, York University, Toronto, Ontario, Canada; ICanCME Research Network, Montreal, Quebec, Canada.
Respiratory physiology & neurobiology
|October 7, 2024
概括
启发性肌肉训练 (IMT) 改善了长期COVID (SARS-CoV-2的急性后续) 和ME/CFS患者的运动能力,自主功能和症状. 这种安全的干预措施为使人虚弱的后病毒状况提供了潜在的缓解.
科学领域:
- 医学研究 医学研究
- 肺部病理学 肺部病理学
- 神经学 神经学
背景情况:
- SARS-CoV-2 (PASC) 或长期COVID的急性后续和肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 是普遍存在的,使人衰弱的后病毒性疾病.
- 这些情况共享重叠的症状,如运动不耐受和自主功能障碍,需要有效的治疗调查.
研究的目的:
- 研究启发性肌肉训练 (IMT) 在缓解症状,增强运动能力和改善PASC和轻度至中度ME/CFS患者的自主功能方面的有效性.
主要方法:
- 进行了一项临床试验 (NCT05196529),涉及8周的IMT.
- 参与者包括健康对照组 (n=12),PASC患者 (n=9),以及轻度至中度ME/CFS患者 (n=12).
- 测量结果包括吸气肌压,运动能力,自主功能和症状学.
主要成果:
- 所有小组在IMT后的灵感肌肉压力,6分钟步行距离,静止心率,心率变化和睡眠症状显著改善.
- 此外,ME/CFS组在血管功能,分泌运动功能,自主症状得分 (COMPASS 31) 和疼痛症状方面也有所改善.
- 在PASC和/或ME/CFS患者中,IMT导致自主功能和症状的整体改善.
结论:
- 八周的IMT是一种安全有效的干预措施,可以改善关键的生理指标,并减少PASC和ME/CFS患者的症状.
- IMT显示出作为一种治疗策略的潜力,用于管理与这些后病毒状况相关的复杂症状.
- 进一步的研究可能会探索PASC和ME/CFS患者的长期影响和个性化的IMT协议.
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