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在轻度创伤性脑损伤中,雷宁-血管酶系统 (RAS) 组件的参与

Caroline Amaral Machado¹, Bruna da Silva Oliveira¹, João Luís Vieira Monteiro de Barros¹

¹Department of Morphology, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

|October 7, 2024

概括

在轻度创伤性脑损伤 (mTBI) 中,Renin Angiotensin系统 (RAS) 发生变化. 用telmisartan或perindopril针对RAS组件在mTBI小鼠模型中改善了行为结果.

科学领域:

神经科学是一个神经科学.
内分泌学在内分泌学.
药理学药理学是指药理学的学科.

背景情况:

氨素系统 (RAS) 与创伤性脑损伤 (TBI) 的病理生理学有关.
在轻度TBI (mTBI) 中RAS参与的证据有限.
在mTBI中调查RAS对于理解脑损伤机制至关重要.

研究的目的:

在动物模型中调查在mTBI后RAS的经典和反调控轴的变化.
确定关键大脑区域RAS组件的时间和半球变化.
评估RAS抑制在mTBI中的治疗潜力.

主要方法:

使用了mTBI的小鼠模型.
在急性和晚期的海马体和前额皮层中评估了ACE,Ang II,AT1R,Ang-(1-7),Mas受体和AT2受体的水平.
给mTBI小鼠的特尔米沙坦 (AT1R阻断剂) 和平原 (ACE抑制剂) 的使用.
评估运动运动活动和类似焦虑的行为.

主要成果:

mTBI小鼠在海马和前额皮质中显示出增强的ACE/Ang II/AT1R轴活性,无论是ipsilaterally还是 contralaterally.
在mTBI后观察到Ang-(1-7) 的增加和Mas受体表达的减少.
在特定的大脑区域上调AT2受体表达.
泰尔米萨坦和印布里尔治疗改善了mTBI诱导的行为缺陷.

结论:

传统和替代RAS轴的组件在mTBI之后以时间和半球依赖的方式被改变.
拉斯在mTBI病理生理学中发挥着重要作用.
针对RAS的药物显示了mTBI治疗的治疗潜力.

关键词:

ангиотензин II 的使用.更多的受体受体.轻微的创伤性脑损伤是轻微的列宁血管氨素系统重量下降模型的重量下降模型

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