对作为癌症患者补充治疗的系统审查
Felix Krannich1, Ralph Mücke2, Jens Büntzel3
1Klinik für Innere Medizin II, Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Am Klinikum 1, Jena 07747, Germany.
Complementary therapies in medicine
|October 7, 2024
概括
补充剂可以通过减少治疗毒性,使缺乏症的癌症患者受益. 然而,证据是混合的,对于大多数癌症患者的整体生存或生活质量没有明确的好处.
科学领域:
- 在瘤学瘤学.
- 营养生物化学 营养生物化学
- 基于证据的医学基于证据的医学.
背景情况:
- (Se) 是一种具有抗氧化特性的微量元素,因其在癌症治疗中的作用而受到广泛研究.
- 关于作为癌症患者的补充疗法的现有证据需要进行批判性评估.
研究的目的:
- 系统地审查和批判性地评估补充剂作为成人癌症患者接受治疗的辅助治疗的有效性.
主要方法:
- 在2023年5月进行了对五个数据库 (Embase,Cochrane,PsychInfo,CINAHL,Medline) 的系统搜索.
- 包括的研究集中在成人癌症患者的替代疗法,并具有预定义的纳入/排除标准.
- 分析了12项研究 (14篇出版物),涉及2483名患者.
主要成果:
- 补充剂显示,在基线缺乏症患者的放射治疗相关毒性减少的潜力.
- 在总生存 (OS),无复发间隔 (RFI),无进展间隔 (PFI),生活质量 (QoL) 或前列腺特异性抗原 (PSA) 水平方面没有观察到显著的益处,无论基线状况如何.
- 在包括的研究中,发现了大量的异质性和对偏差风险的担忧.
结论:
- 补充剂在癌症患者的有效性是不确定的,因为异质的结果和方法的限制.
- 在放射或化疗期间,癌症患者的确诊缺乏可能会从补充中受益.
- 未来的研究应该优先考虑缺乏症作为纳入标准,并在整个干预过程中监测水平.
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