在一项随机结直肠癌查试验中,结直肠镜检查后的不良反应
Øyvind Bakken Rognstad1,2,3,4, Edoardo Botteri1,5, Geir Hoff1,6
1Cancer Registry of Norway, Section for Colorectal Cancer Screening, Norwegian Institute of Public Health, Oslo, Norway.
BMJ open gastroenterology
|October 7, 2024
概括
结肠镜查结肠直肠癌 (CRC) 的不良事件不常见,影响约2.4%的手术. 大多数事件都是轻微的,但对风险因素的认识可以帮助提高患者的安全.
科学领域:
- 胃肠病学和内镜检查
- 公共卫生和查计划
- 临床试验研究 临床试验研究
背景情况:
- 结肠镜检查是结肠直肠癌 (CRC) 查的一个关键程序.
- 与结肠镜相关的不良事件有助于CRC查的整体负担.
- 本研究调查了挪威大型CRC查试验中的结肠镜相关不良事件.
研究的目的:
- 评估结肠镜检查期间和之后发生的不良事件的发生率和类型.
- 为了确定与结肠镜相关的不良事件相关的风险因素.
- 为在CRC查计划中减轻风险的策略提供信息.
主要方法:
- 2012年至2020年间接受结肠镜检查的个体的横截面分析.
- 关于不良事件的数据从医疗记录中提取,并使用ASGE词典进行分类.
- 使用多变量逻辑回归来确定不良事件的风险因素.
主要成果:
- 在10,244人中,有2.4%的人经历了至少一个结肠镜检查相关的不良事件.
- 大多数事件是轻度 (1.8%),中度 (0.49%) 或严重 (0.03%) 的事件较少.
- 关键的危险因素包括年龄较大,女性性别,抗凝药疗法和被切除的病变的特征.
结论:
- 结肠镜检查不良事件发生在约2%的查程序中,大多数是轻微的.
- 鉴定和理解风险因素对于内镜师来说至关重要,以尽量减少潜在的危害.
- 这些数据支持正在进行的努力,以优化通过结肠镜检查CRC查的安全性.
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