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乳腺癌幸存者的生物衰老的转录体标志物:一项纵向研究

Judith E Carroll^1,2,3, Catherine M Crespi^3,4, Steve Cole^1,2,3,5

¹Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.

Journal of the National Cancer Institute

|October 7, 2024

概括

乳腺癌治疗加速生物衰老,通过免疫细胞中细胞衰老和DNA损伤标记的增加来表明这一点. 与单独的辐射相比,有或没有辐射的化疗显示出持续的衰老效应.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
衰老研究研究衰老研究

背景情况:

乳腺癌疗法可以影响长期的健康和衰老过程.
了解治疗诱导衰老的分子机制对于幸存者护理至关重要.

研究的目的:

研究乳腺癌治疗对生物衰老标志物的影响.
分析与细胞衰老,DNA损伤和治疗后炎症相关的基因表达.

主要方法:

在放射治疗 (RT) 和/或化疗 (CT) 之前和后2年内对患有乳腺癌 (阶段0-III) 的妇女进行长度研究.
对外围血液单核细胞的RNA测序,以评估基因表达.
使用混合线性模型和零膨胀两部分模型进行统计分析.

主要成果:

与RT或单独手术相比,使用或不使用放射治疗 (RT) 的化疗 (CT) 与治疗后检测到p16INK4a表达的几率更高.
所有治疗组都显示了p16INK4a,DNA损伤反应,SenMayo和老化相关的分泌表型随着时间的推移而增加.
与单独RT相比,使用或不使用RT的化疗显示出DNA损伤反应,SenMayo和衰老相关的分泌表型增加的明显模式.

结论:

乳腺癌治疗激活与生物衰老相关的基因,包括细胞衰老和炎症反应,从诊断到早期生存.
虽然在治疗过程中观察到衰老标志物的增加,但化疗导致持续增加,而放射治疗后来显示出减缓效果.
研究结果表明,接受乳腺癌治疗的妇女的免疫细胞表现出加速的生物衰老.

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