在人类质母细胞瘤中,通过非编码RNA调节自
Mehran Molavand1, Niloufar Ebrahimnezhade2, Arash Kiani3
1Student Research Commitee, Tabriz University of Medical Sciences, Tabriz, Iran.
Medical oncology (Northwood, London, England)
|October 7, 2024
概括
非编码RNAs (ncRNAs) 调节质母细胞瘤的自,影响癌症的进展和治疗耐药性. 针对ncRNA调节的自为这种侵袭性脑癌提供了一个有前途的新疗法策略.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 质母细胞瘤是一种侵袭性脑癌,由于对标准疗法的耐药性,治疗结果不佳.
- 自在质母细胞瘤细胞存活和进展中起着关键作用,特别是在压力严重的条件下.
- 非编码RNAs (ncRNAs) 是细胞过程的关键调节者,包括基因表达和恒温.
研究的目的:
- 审查ncRNAs调节质母细胞瘤自的复杂机制.
- 探索微RNAs (miRNAs),长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs) 在质母细胞瘤自中的作用.
- 讨论在质母细胞瘤治疗中准ncRNA调节的自的治疗潜力.
主要方法:
- 关于ncRNAs,自和质母细胞瘤的当前研究的文献评论.
- 对关键自途径的ncRNA调节的分析 (例如AMPK/mTOR,PI3K/AKT).
- 专注于ncRNAs,自和质母细胞细胞增殖,入侵和治疗反应之间的相互作用.
主要成果:
- ncRNAs,包括miRNAs,lncRNAs和circRNAs,是质母细胞瘤自调节的组成部分.
- 这些ncRNAs影响关键的自途径,影响质母细胞细胞的行为和治疗结果.
- 通过ncRNA介导的自失调有助于质母细胞瘤的攻击性和治疗耐药性.
结论:
- ncRNAs是质母细胞瘤自的关键调节者,影响其进展和对治疗的反应.
- 准ncRNA调节的自是一种有前途的治疗途径,用于质母细胞瘤治疗.
- 需要进一步研究不同ncRNAs在质母细胞瘤自中的特定作用和相互作用.
相关概念视频
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
01:27Autophagy
4.2K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.2K
02:39lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
01:22PI3K/mTOR/AKT Signaling Pathway
3.4K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.4K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
01:23Regulation of Expression at Multiple Steps
875
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
875