循环时钟失调:阻塞性睡眠呼吸暂停患者抑郁症的潜在机制
Agata Gabryelska1, Szymon Turkiewicz2, Piotr Kaczmarski2
1Department of Sleep Medicine and Metabolic Disorder, Medical University of Lodz, Lodz, Poland. agata.gabryelska@gmail.com.
Translational psychiatry
|October 7, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 与抑郁症有关. 在患有更严重抑郁症状的OSA患者中,生理时钟基因表达失调,这表明被破坏的生理时节节律有助于情感症状.
科学领域:
- 睡眠医学 睡眠医学
- 时间生物学 时间生物学
- 精神病学是一个精神病学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 经常与情绪障碍,特别是抑郁症同时发生.
- 循环节律障碍与OSA和情绪障碍有关.
- 了解将OSA与抑郁症联系在一起的分子机制对于开发有针对性的疗法至关重要.
研究的目的:
- 研究OSA患者的昼夜钟基因表达和抑郁症状之间的关联.
- 为了比较OSA患者和健康对照者之间的基因表达模式.
- 为了确定OSA患者抑郁症严重程度的预测因素.
主要方法:
- 184人接受了多睡眠图 (PSG) 和血液采集.
- 周围血液白细胞被用于对昼夜钟基因 (BMAL1,CLOCK,PER1,CRY1,NPAS2,NR1D1) 的qRT-PCR分析.
- 用蒙哥马利-阿斯伯格抑郁评分表 (MADRS) 以及其他问卷来评估抑郁症状.
主要成果:
- 在OSA患者 (NPAS2除外) 中,心脏时钟基因表达在早上与晚上相比上调.
- 在OSA和对照组之间没有发现基因表达的显著差异.
- 抑郁症的严重程度 (MADRS评分) 与OSA患者的昼夜基因的早晨表达有正相关.
- 失眠严重程度指数 (ISI),早晨的年代型问卷 (CQ) 得分,以及早晨的PER1基因表达预测了抑郁症严重程度.
结论:
- 在OSA患者中,失调的昼夜钟基因表达与抑郁症状的严重程度有关.
- 循环节障碍可能是OSA中观察到的情感症状的一个因素.
- 对OSA相关抑郁症的昼夜干预进行进一步的研究是有必要的.
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