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Updated: Jun 11, 2025

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
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PC-ME1代谢轴的补偿活性是对线粒体复合物I抑制的差异敏感性的基础

Lucia Del Prado1, Myriam Jaraíz-Rodríguez1, Mauro Agro1

  • 1Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain.

Nature communications
|October 7, 2024
PubMed
概括

电子输送链 (ETC) 的抑制导致线粒体疾病. 一个非正规的TCA循环维持NADPH,而不是ATP,其介质解释了差异性的细胞敏感性,影响疾病管理.

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