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Updated: May 12, 2026

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Published on: November 7, 2018

在1920年至2024年期间恢复的沙门氏菌 (Salmonella Gallinarum) 全球基因组数据集

Chenghao Jia^1,2, Linlin Huang^1,2, Haiyang Zhou^1,2,3

¹Institute of Preventive Veterinary Sciences and Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, 310058, China.

Scientific data

|October 7, 2024

概括

这项研究提供了最大的沙门氏菌 (Salmonella Gallinarum) 基因组数据集,揭示了抗菌素耐药性基因和移动元素. 本资源有助于了解禽类伤寒和改善家禽健康管理.

科学领域:

兽医微生物学兽医微生物学
基因组学就是基因组学.
鸟类病理学鸟类病理学

背景情况:

沙门氏菌 (Salmonella enterica serovar Gallinarum,S.Gallinarum) 导致禽类伤寒,这是一种高死亡率的疾病.
养业,特别是中国的养业,由于禽类伤寒而面临重大经济损失.
对S. Gallinarum缺乏全面的基因组数据,这阻碍了有效的疾病控制.

研究的目的:

创建S. Gallinarum最广泛的基因组数据集.
分析基因组特征,包括抗菌素耐药性和移动遗传元素.
为未来关于禽类伤寒的研究提供一个有价值的资源.

主要方法:

编制了574个S. Gallinarum基因组 (366个新测序,208个公开).
在 silico 预测中用于 biovar 分类.
分析了抗微生物耐药性基因 (ARG) 和移动基因组元素 (MGE).

主要成果:

该数据集包括来自全球不同地点和时间段的574个S. Gallinarum基因组.数据集包括来自全球不同地点和时间段的574个S. Gallinarum基因组.
S. Gallinarum被分为三个不同的生物种.
41.5%的菌株携带ARG,其中40.4%呈现多药耐药性.
5,636个MGEs,主要是菌体和质粒,被确定为ARG的驱动因素.

结论:

这一全面的数据集增强了对S. Gallinarum基因组多样性和演变的理解.
这些发现突显了S. Gallinarum中抗菌素耐药性和移动遗传元素的普遍性.
该数据集是制定针对禽类伤寒的改进策略的关键资源.

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