患有急性胰腺炎的重症患者中核红细胞的分布:一项追溯队列研究
Huan-Qin Liu1, Guan-Qun Wang1, Cheng-Shuang Zhang1
1Department of Critical-care Medicine, Jining NO.1 People's Hospital, Jining, 272000, Shandong Province, China.
BMC gastroenterology
|October 7, 2024
概括
核化红细胞 (NRBC) 的增加与急性胰腺炎的危急病患者的死亡率更高相关. 这一发现表明NRBC水平可以帮助预测患者的结果.
科学领域:
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
- 胰腺学 胰腺学
背景情况:
- 有限的研究存在于核红细胞 (NRBC) 和急性胰腺炎 (AP) 危急病患者的死亡率之间的关联.
- 了解AP死亡率的预测因素对于改善患者的治疗结果至关重要.
研究的目的:
- 为了研究NRBC水平和AP的危急病患者的死亡率之间的潜在关联.
- 评估NRBC对该患者群体死亡率的预测值.
主要方法:
- 使用MIMIC-IV和MIMIC-III数据库进行回顾性队列研究.
- 非线性关联的受限制立方线 (RCS) 回归和预后评估的通用线性模型 (GLM).
- 开发四种机器学习模型 (GBC,随机森林,高斯天真贝叶斯,决策树) 以使用NRBC和其他临床变量预测90天死亡率.
主要成果:
- 观察到NRBC水平与90天死亡率之间存在非线性关系.
- 1.7%的NRBC截止值显示了90天死亡率的中度预测能力 (AUC0.599).
- 升高的NRBC水平与90天死亡风险的增加显著相关 (OR > 1,P < 0.05).
- 梯度增强分类器 (GBC) 模型显示了90天死亡率的高预测准确性 (AUC 0.982).
结论:
- 升高的NRBC水平与患有AP的重症患者的死亡风险增加有关.
- NRBC显示出作为急性胰腺炎死亡率预测标记物的潜力.
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