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Updated: Jun 11, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Published on: April 26, 2017

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在癌症中,APC突变调节了癌症中替代性多基解的失调.

Austin M Gabel1,2,3,4, Andrea E Belleville1,2,3,5, James D Thomas1,2

  • 1Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Genome biology
|October 7, 2024
PubMed
概括

在结直肠癌中,APC基因的丢失会破坏替代多基解 (APA),导致广泛的基因表达变化. 这一发现揭示了一种推动癌症发展的新机制.

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