伊朗马什哈德的HPV基因型分布:2022-2023年研究的见解
Arash Letafati1,2, Masoomeh Noroozi2, Tina Fallah2
1Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Virology journal
|October 7, 2024
概括
人类乳头瘤病毒 (HPV) 感染影响了伊朗马什哈德30%的患者,其中HPV-6和HPV-16是最常见的基因型. 这种患病率突显了与HPV相关的癌症的潜在风险,特别是来自目前疫苗未覆盖的基因型的癌症.
科学领域:
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 人类乳头瘤病毒 (HPV) 是子宫癌的主要原因,也是常见的性传播感染 (STI).
- HPV与各种癌症有关,包括口腔,阴茎,喉,口腔,门,部和阴道癌症.
- 了解HPV基因型分布对于公共卫生战略和癌症预防至关重要.
研究的目的:
- 确定HPV基因型在伊朗马什哈德患者中的流行和分布.
- 在被研究的人群中识别常见和不太常见的HPV基因型.
- 评估HPV基因型流行对疫苗接种和癌症风险的影响.
主要方法:
- 在2022年1月至2023年2月期间,共分析了428名参与者 (382名女性,46名男性).
- 收集了宫拭片和尿液样本用于HPV DNA提取和基因定型.
- 统计分析包括曼·惠特尼U测试和Chi-square测试,以评估患病率和分布.
主要成果:
- 在30.1%的参与者 (428人中129人) 中检测到HPV感染.
- 最常见的基因型是HPV-6 (10.3%),HPV-16 (8.7%) 和HPV-51 (7.7%).
- 还确定了HPV-39 (6.7%) 和其他基因型,如HPV-11,HPV-61,HPV-91和HPV-44 (1%).
结论:
- 马什哈德人群中的HPV总体患病率约为30%.
- 观察到HPV-6和HPV-16的显著流行,这些是疫苗向的基因型.
- 不被加达西尔疫苗所覆盖的HPV-51和HPV-39基因型的存在表明,未来可能存在相关癌症的风险.
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