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Updated: Jun 11, 2025

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
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USP15通过使MeCP2脱和稳定MeCP2来抑制缺氧诱导的IL-6信号传递

Zi-Tong Zhang1, Shu-Xuan Niu1, Chen-Hao Yu1

  • 1School of Pharmacy, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.

The FEBS journal
|October 8, 2024
PubMed
概括

乌比奎丁特异性蛋白酶15 (USP15) 稳定了甲基-CpG结合蛋白2 (MeCP2),通过防止其在缺氧下降解. 这种调节会影响IL-6 (IL-6) 信号传递,从而提供有关神经发育障碍的见解.

关键词:
在IL-6信号传输中.这就是MeCP2的意义.美国15 USP必须进行脱离分离.缺氧 缺氧是指缺氧的情况.

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