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相关概念视频

Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Spermatogenesis01:41

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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相关实验视频

Updated: Jun 11, 2025

Combined Supine and Standing Imaging for Varicocele: An Improved Diagnostic Approach
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精子DNA碎片化指数是否随着时间的推移在静脉引发不孕症的静脉切除术后持续下降? 一个系统的审查和元分析.

Lihong Wang1,2, Lei Zheng1,2, Hui Jiang3

  • 1Department of Andrology and Sexual Medicine, The Second Hospital of Dalian Medical University, Dalian, China.

American journal of men's health
|October 8, 2024
PubMed
概括

经过静脉切除术后的6个月显示精子DNA碎片化指数 (DFI) 的最佳改善,表明受孕的有利时间. 需要进一步的研究来证实这些关于男性不孕症治疗时间的发现.

关键词:
基因分裂指数是DNA的碎片化指数.不孕不育 不孕不育 不孕不育这种疾病的发病率是Varicocele.进行多样性切除 (varicocelectomy).

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科学领域:

  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 生殖医学 生殖医学
  • 安德罗学与人类学

背景情况:

  • 腹 (VC) 是男性不孕症的主要可逆原因之一.
  • 静脉切除术是一种常见的治疗方法,但精子质量改善的最佳术后时间尚不清楚.

研究的目的:

  • 确定静脉切除术后理想的等待期,以显著改善精子DNA碎片化指数 (DFI).
  • 根据 DFI. 确定经过静脉切除术后的最佳受孕时间.
  • 通过元分析来综合现有证据.

主要方法:

  • 使用主要科学数据库 (PubMed,Embase,Scopus,Web of Science,Cochrane Library) 进行了已发表研究的元分析.
  • 来自四项纳入研究的数据被汇总在一起,以计算DFI变化的平均差异 (MD) 和95%置信区间 (CI).
  • 使用I平方 (I2) 统计学来评估异质性.

主要成果:

  • 与手术前状态相比,精子DFI在经过静脉切除术后3个月内显著改善 (MD: -3.66).
  • 在手术后6个月,与手术后3个月相比,精子DFI的进一步显著改善被观察到 (MD: -1.51).
  • 在经过静脉瘤切除术12个月后,没有发现精子DFI的显著额外改善 (MD: -1.59,p=0.06).

结论:

  • 六个月似乎是静脉瘤切除术后的最佳时间,以实现精子DFI的最佳改善.
  • 这6个月的间隔可能代表了经过静脉切除术后试图怀孕的最有利时期.
  • 需要进一步的精心设计的前性研究来验证这些发现.