大动脉的功能和大动脉尺寸在肥胖和超重的患者与双管大动脉的双管大动脉
Andrew M Reittinger1, Peter N Dean2, Michael A McCulloch2
1Department of Pediatric Cardiology, Virginia Commonwealth University, Richmond, VA, USA.
Cardiology in the young
|October 8, 2024
概括
超重和肥胖的儿童双大动脉显示出更大的大动脉尺寸和更差的门功能. 这突显了体重对儿科先天性心脏病中的心血管健康的影响.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 遗传性心脏病研究 遗传性心脏病研究
- 肥胖和心血管健康 肥胖和心血管健康
背景情况:
- 双动脉 (BAV) 是最常见的先天性心脏缺陷 (CHD).
- BAV通常与活动限制有关,可能导致久坐不动的生活方式和肥胖风险增加.
- 肥胖对有BAV的年轻人大动脉尺寸和门功能的影响尚不清楚.
研究的目的:
- 为了调查与健康体重同龄人相比,患有BAV的超重和肥胖儿童是否表现出大动脉尺寸变化或大动脉功能受损.
- 评估儿科BAV患者体重状况和心血管参数之间的关系.
主要方法:
- 一项回顾性队列研究涉及251名年龄在5至25岁的患者,他们被诊断患有BAV.
- 患者被分为健康体重和超重/肥胖的组.
- 大动脉尺寸和峰值/平均大动脉梯度是从心声回声图报告中分析的.
主要成果:
- 超重/肥胖患者在按身高进行索引时,大动脉环和鼻管结显著增加 (p < 0.05).
- 两组之间对大动脉根或上升大动脉尺寸没有发现显著差异.
- 超重/肥胖组与健康体重组相比,表现出较高的峰值大动脉梯度 (p = 0.003).
结论:
- 在这个BAV队列中,健康体重与较大的大动脉尺寸没有相关性.
- 有证据表明,在患有BAV的超重/肥胖儿科患者中,大动脉狭窄症的恶化.
- 体重管理可能对改善年轻BAV患者心血管结果至关重要.
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