在缺血性中风患者中检查出血病学参数
Gursan Gunes Uygun1, Sena Ebru Caglar2, Kemal Tutkavul1
1Department of Neurology, University of Health Sciences, Istanbul Haydarpasa Numune Research and Training Hospital, Istanbul, Turkey.
International journal of laboratory hematology
|October 8, 2024
概括
急性缺血性中风与增加的红细胞聚合有关. 增强的红细胞变形性可能是一个补偿机制,中风风险因素与特定的大脑区域相关.
科学领域:
- 血液学 血液学 血液学
- 神经学 神经学
- 血管生物学 血管生物学
背景情况:
- 在急性缺血性中风中,诸如全血粘度 (WBV),血粘度,红细胞聚合和可变性等血液病理参数至关重要.
- 了解这些参数的变化及其与中风病因学的关系对于患者管理至关重要.
研究的目的:
- 为了研究急性缺血性中风患者的血液学参数变化.
- 为了将这些变化与中风病因,风险因素和神经成像发现相关联.
- 为了观察治疗后血液病学参数的时间变化.
主要方法:
- 一项前性观察性研究,涉及70名急性缺血性中风患者和96名健康对照.
- 在入院和治疗后使用激光细胞检测和旋转粘度计测量出血病学参数.
- 使用TOAST标准对中风患者进行分类.
主要成果:
- 与对照人群相比,中风患者在红细胞聚合 (幅度,指数,半衰期) 和升高的延伸指数中表现出显著差异.
- 两组之间没有发现WBV或血粘度的显著差异.
- 同型半氨酸水平与特定大脑区域的白质病变正相关.
结论:
- 红细胞聚合增加可能会使个体易患急性缺血性中风.
- 红细胞变形性可能在慢性血管疾病中起到补偿机制的作用.
- 缺血性中风风险因素与不同的大脑区域有关.
更多相关视频
09:48Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
Published on: May 4, 2015
13.8K
10:41Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
Published on: June 3, 2021
3.6K
相关概念视频
Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
