母亲精神障碍和新生儿后果:丹麦基于人口的队列研究
Natalie C Momen1, Hannah Chatwin1, Katrine Holde1
1National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.
概括
母亲精神障碍与新生儿不良后果的风险增加有关,包括低出生体重和早产. 持续的心理健康状况带来了最高的风险,强调了对母亲支持的需要.
科学领域:
- 围产期心理健康研究
- 新生儿结局研究研究.
- 孕产妇精神疾病的流行病学
背景情况:
- 以前的研究将母亲的精神障碍与不良出生结果联系起来,但往往忽略了全方位的疾病.
- 为了全面理解,需要检查所有类型的孕产妇精神障碍及其对新生儿的影响.
研究的目的:
- 调查整个母亲精神障碍和一系列新生儿不良结果之间的联系.
- 为了在大量人群中更全面地了解这些关键的关联.
主要方法:
- 在丹麦 (1997-2015年) 进行的一项大型队列研究包括超过110万个活生生的独生子.
- 对比新生儿结果 (例如,低出生体重,早产,阿普加尔得分,新生儿死亡) 对于母亲的婴儿过去,最近,或持久的精神障碍诊断与那些没有诊断.
- 计算各种不利结果的几率比率和95%置信区间.
主要成果:
- 暴露于母亲精神障碍,特别是持久性疾病的儿童面临着几乎所有新生儿不良后果的风险增加.
- 对于大多数结果,在"持久"的母亲精神障碍组中观察到的风险最高.
- 一个例外是持续的母亲精神障碍和新生儿死亡之间的关联,这表明没有显著的增加 (OR 0.96,95% CI 0.62-1.48).
结论:
- 这项研究证实,患有精神障碍的母亲出生的婴儿患有多种新生儿不良后果的风险增加.
- 强调加强对孕妇和面临心理健康挑战的母亲的监测和支持系统的迫切需要.
- 强调在产前护理中解决母亲心理健康的全方位的重要性.
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