在接受脏移植的患者中,高的内科塔克罗利斯变异性和增加的无细胞DNA
Miranda Kopfman1,2, Marissa Brokhof1, Shree Patel3
1Department of Pharmacy, Rush University Medical Center, Chicago, IL, USA.
概括
塔克罗利马斯水平的高变化可能会增加移植受体的捐赠者衍生细胞自由DNA (dd-cfDNA). 这表明塔克罗利斯的变异性是监测移植健康状况的潜在生物标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植免疫学 移植免疫学
- 药物基因组学 药物基因组学
背景情况:
- 塔克罗利木斯是移植中关键的免疫抑制剂.
- 捐赠者衍生的无细胞DNA (dd-cfDNA) 是固体器官移植排斥的生物标志物.
- 关于移植受体中塔克罗利斯变异性和dd-cfDNA之间的关系的数据有限.
研究的目的:
- 为了研究高塔克罗利斯变异性和高dd-cfDNA水平之间的关联.
- 为了检查脏和同时胰腺脏移植接受者的这种关系.
主要方法:
- 脏和胰腺-脏移植接受者的回顾性,单中心研究.
- 在移植后1-12个月期间,通过变化系数 (%CV) 评估的塔克罗利莫斯变异性.
- 使用了纵向的dd-cfDNA监测.
主要成果:
- 胰腺-脏接受者显示了更高的中位数dd-cfDNA,并被排除在外.
- 分析了99名脏移植接受者.
- 与%CV<30% (0.22%对0.17%,P=.031) 的患者相比,TACROLIMUS %CV ≥30%的接受的dd-cfDNA中位数显著更高.
结论:
- 高的内科塔克罗利斯变异性与在移植后的第一年增加的dd-cfDNA有关.
- 塔克罗利莫斯的变异性可能作为预测移植接受者的移植健康的标志物.
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