在患有冠心病的老年患者中,FT3/FT4和虚弱的相关性分析
Jiling Qu1, Siqi Ji2, Ting Zhou3
1Jiangsu Vocational College of Medical, Yancheng, Jiangsu, China. 1450868213@qq.com.
Endokrynologia Polska
|October 8, 2024
概括
甲状腺激素水平,特别是T3和FT3/FT4比率,与冠状动脉心脏病 (CHD) 的老年患者的虚弱有关. 较低的水平表明风险增加,强调需要进行临床监测.
科学领域:
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
- 心脏病学 心脏病学
背景情况:
- 在老年人群中,脆弱性越来越令人担忧,特别是那些患有心血管疾病的人群中.
- 甲状腺激素 (TH) 在新陈代谢调节中起着至关重要的作用,并与脆弱性有关.
- 关于TH与冠状动脉疾病 (CHD) 的老年患者的脆弱性之间的特定关系的研究有限.
研究的目的:
- 调查甲状腺激素水平与老年患者诊断为心脏病的虚弱风险之间的关联.
- 为了确定各种甲状腺激素指数在这个特定的患者队列中对脆弱性的预测值.
主要方法:
- 用Fried脆弱度表进行参与者评估.
- 雇佣接收器操作特征 (ROC) 曲线分析,以评估甲状腺激素对脆弱性的预测准确性.
- 应用多变量逻辑回归来分析甲状腺激素水平和脆弱性之间的关系,调整混因素.
主要成果:
- 这项研究包括277名老年心血管疾病患者,其中29.96%的患者表现出虚弱.
- 自由三甲状腺素与自由甲状腺素 (FT3/FT4) 的比率显示出对脆弱性的最高预测值 (曲线下的面积=0.634).
- 在调整人口统计和临床变量后,较低的T3,FT3和FT3/FT4水平被确定为虚弱和前虚弱的显著风险因素.
结论:
- 与单个甲状腺激素测量相比,FT3/FT4比率提供了更准确的脆弱性预测.
- 特定的T3 (≤1.095nmol/L),FT3 (≤4.085pmol/L) 和FT3/FT4 (≤0.336) 的值被确定为影响脆弱性的因素.
- 低T3水平独立地预测了前脆弱性,强调了监测甲状腺功能的重要性,以早期检测心脏病患者的脆弱性.
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