在高血压患者中,甘油三糖指数和射出分数之间的关联保留了心力衰竭
Xue-Feng Shan1,2,3, Long Yang1, Xiao-Ming Gao1,2,3
1State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia; Pediatric Cardiothoracic Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
PeerJ
|October 8, 2024
概括
甘油三糖 (TyG) 指数是胰岛素耐药性的标志物,在患有基本高血压的患者中,与心力衰竭与保留射出分数 (HFpEF) 有显著的关联. 这一发现表明代谢功能障碍在HFpEF发育中起着关键作用.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 高血压研究 高血压研究
背景情况:
- 甘油三糖 (TyG) 指数是心血管疾病的公认预测指标,也是胰岛素抵抗 (IR) 的替代品.
- 在基本高血压患者中,TyG指数和心力衰竭与保存的喷射分数 (HFpEF) 之间的关系以前未确立.
研究的目的:
- 在被诊断患有基本高血压的患者中调查TyG指数和HFpEF之间的相关性.
- 评估TyG指数在这个人群中对HFpEF的预测值.
主要方法:
- 对992名高血压患者进行了回顾性研究.
- 使用了斯皮尔曼相关性,物流回归,受限立方线和ROC曲线分析.
- 根据TyG指数分层对患者进行分层,以评估风险因素.
主要成果:
- 较高的TyG指数第三种动物与增加的HFpEF风险因素有关,如年龄,BMI,SBP,NT-proBNP和LVMI.
- 在TyG指数和HFpEF (OR 5.127) 之间发现了显著的独立关联.
- 在TyG指数和HFpEF发生率之间存在非线性,S形关系;TyG指数,NT-proBNP和LVMI显示出良好的预测能力,TyG+LVMI组合最强 (AUC 0.907).
结论:
- 用TyG指数表示的胰岛素耐药性与高血压患者的HFpEF发展有显著的关联.
- 代谢功能障碍在HFpEF病理生理学中至关重要.
- 对高血压心血管风险管理的综合方法应考虑代谢因素.
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