生物膜产生的生物及其在慢性辅助性中耳炎中对抗生素的敏感性:一个横截面研究
Zaaraasmat Ahesannawaz Mujahid1, Shilpa Saji Palal1, Gopika Gopan1
1Department of Otorhinolaryngology, Bangalore Medical College and Research Institute, Bangalore, Karnataka India.
概括
生物膜对慢性辅助性中耳炎 (CSOM) 和抗生素耐药性有显著的贡献. 对生物膜形成的查对于有效的CSOM治疗和对抗多药物耐药性至关重要.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 慢性辅助性中耳炎 (CSOM) 的特征是中耳裂炎症.
- 细菌生物膜越来越多地被认为是CSOM病原体的关键贡献者.
- 生物膜促进抗生素耐药性,基因交换和免疫逃避.
研究的目的:
- 为了确定CSOM中生物膜产生细菌的范围.
- 评估这些产生生物膜的细菌对抗生素的敏感性.
- 突出生物膜查在CSOM管理中的临床影响.
主要方法:
- 从CSOM患者的外部听觉介质收集了648个样本.
- 处理的样本用于细菌培养和抗生素敏感性测试.
- 在细菌分离物中检测和量化了生物膜的形成.
主要成果:
- 伪 (62.6%) 和MRSA (13.8%) 是500个培养阳性样本中最常见的分离物.
- 70%的分离物产生了生物膜,其中Pseudomonas是最常见的生产者 (74.6%).
- 亨塔米辛对生物膜制造者表现出最高的疗效,而阿莫西西林 - 克拉夫兰酸,塞夫特里亚克,塞福洛キシ姆和米诺环素表现出耐药性.
结论:
- 多种药物耐药性在CSOM病原体中普遍存在,特别是生物膜生产者.
- 对于CSOM协议,建议在抗生素图谱的同时进行生物膜形成的例行查.
- 整合生物膜评估将改善治疗选择,并解决抗菌素耐药性问题.
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