阻塞性睡眠呼吸暂停和结石之间的联系:NHANES 2015-2018年和孟德尔随机化
Ying Liu1, Li Wang2, Er-Hao Bao1
1Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People's Republic of China.
Nature and science of sleep
|October 8, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 与较高的结石患病率有关. 对OSA的遗传倾向可能会因果性地增加结石风险,这表明OSA的管理可以减轻石头的发生.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 肺部病理学 肺部病理学
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种普遍的疾病,有许多相关的健康并发症.
- OSA和结石之间的关系仍未得到充分探索,需要进一步调查.
- 了解这种联系对于全面的患者管理至关重要.
研究的目的:
- 调查阻塞性睡眠呼吸暂停 (OSA) 与患结石风险之间的关联.
- 为了确定患有OSA风险的个体是否有结石的发病率增加.
- 使用遗传方法探索潜在的因果关系.
主要方法:
- 一项采用国家健康和营养检查调查 (2015-2018) 数据的横截面研究.
- 进行了后勤回归分析,以评估OSA和结石之间的相关性,计算几率比率 (ORs) 和95%置信区间 (CI).
- 用五种不同的双样本门德尔随机化技术来评估因果关系并最大限度地减少观察偏差.
主要成果:
- 在对混因素进行调整后,在阻塞性睡眠呼吸暂停 (OSA) 和较高的结石患病率 (OR = 1.29;95% CI: 1.00-1.66) 之间发现了统计学上显著的正相关性.
- 门德尔的随机化分析,特别是反变量加权方法,表明在OSA遗传倾向和结石风险增加之间存在潜在的因果关系 (OR: 1.00221,95% CI 1.00056-1.00387).
结论:
- 阻塞性睡眠呼吸暂停 (OSA) 似乎促进结石的形成.
- 对OSA有效的治疗和管理策略可能有助于改善或减少结石的发生.
- 需要进一步的研究来阐明这种关联背后的机制.
更多相关视频
07:45Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
3.6K
11:47Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
Published on: March 4, 2022
2.2K
相关概念视频
01:27Urinary Tract Calculi IV: Nutrition therapy and prevention
2
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
2
01:30Urinary Tract Calculi III: Medical Management
2
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
2
01:28Urinary Tract Calculi I: Introduction
2
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
2
01:11Genome-wide Association Studies-GWAS
13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.2K
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
2
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
2
01:25Urinary Tract Calculi VI: Surgical Management
2
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
2