系统性免疫炎症指数与美国老年人中前列腺癌的高风险有关:来自NHANES 2001-2010年的证据
Ran He1, Youjun Ye2, Qilei Zhu2
1The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Frontiers in oncology
|October 8, 2024
概括
系统性免疫炎症指数 (SII) 与老年男性前列腺癌 (PCa) 的风险更高有关. 这种炎症标志物显示出与PCa风险的U形关联,表明潜在的临床相关性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 系统性免疫炎症指数 (SII) 是一种被公认的系统性炎症标志物.
- 目前的证据缺乏SII和前列腺癌 (PCa) 风险之间的明确联系.
- 调查像SII这样的炎症标志物对于了解PCa病因至关重要.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 与老年美国男性前列腺癌 (PCa) 风险之间的关联.
- 分析与SII和PCa风险相关的血清总前列腺特异性抗原 (tPSA) 和自由前列腺特异性抗原 (fPSA).
- 探索SII作为PCa预测生物标志物的潜力.
主要方法:
- 利用了NHANES数据库 (2001-2010) 中老年男性参与者的数据.
- 使用血小板计数,中性粒细胞计数和淋巴细胞计数计算SII.
- 使用多变量逻辑回归,受限立方线曲线和子组分析来评估SII-PCa风险关系,将高风险定义为tPSA> 4 ng/ml和fPSA% < 16%.
主要成果:
- 总共有2664名参与者被分析,其中137人 (5.14%) 被确定为PCa的高风险.
- 多变量逻辑回归显示,增加的SII和高PCa风险之间存在显著的正相关性 (p=0.009).
- 限制性立方线分析表明,SII和高PCa风险之间存在非线性,U形的关联 (p为非线性=0.028),SII=9.01.01时出现了转折点.
结论:
- 这些发现表明,SII所示的炎症与老年男性前列腺癌风险增加有关.
- SII可以作为PCa风险分层的潜在指标.
- 需要进一步的研究来阐明SII-PCa关联背后的机制.
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