Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

341
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
341
Aging01:26

Aging

38
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
38
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

106
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
106
Anxiolytic Drugs: Overview01:26

Anxiolytic Drugs: Overview

238
Anxiolytic drugs are vital in managing anxiety disorders by effectively alleviating symptoms such as excessive fear, tachycardia, and tremors. There are several classes of anxiolytic medications, each with unique mechanisms of action and potential side effects.
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
238
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

292
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
292
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

2.2K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Auricular Vagus Nerve Stimulation Combined with Physical Therapy for Individuals with Parkinson's Disease: A Pilot Randomized Sham-Controlled Trial.

Neurology international·2026
Same author

Mechanisms associated with tDCS as an adjuvant to shortened phonomotor treatment in chronic post-stroke aphasia.

Neuroimage. Reports·2026
Same author

Are We Treating More Than Pain? Restless Legs Syndrome Outcomes After Lumbar Laminectomy for Radiculopathy.

Neurosurgery·2026
Same author

Interlobular Septal Thickening: A Pictorial Review.

Journal of computer assisted tomography·2026
Same author

The neuroplasticity-based model (NBM): an updated neurorehabilitation model that emphasizes evidence-informed strategies to induce neuroplastic changes.

Disability and rehabilitation·2026
Same author

Functional Reorganization of Motor Subcircuits in Parkinson's disease.

bioRxiv : the preprint server for biology·2026
Same journal

The Geometric Signatures of Brain State Transitions: Recursive Informational Curvature Reveals Hidden Dynamics in Primate Cortex.

Neuroscience insights·2026
Same journal

Neuromodulation of Working Memory: Mechanisms, Targets, and Behavioral Outcomes.

Neuroscience insights·2026
Same journal

Effects of Sex, Estradiol, and Acute Stress on Spontaneous Recovery of a Conditioned Touchscreen Response in Rats.

Neuroscience insights·2026
Same journal

Activity and State-Dependent Modulation of Salt Taste Behavior Via Pharyngeal Neurons in <i>Drosophila melanogaster</i>.

Neuroscience insights·2026
Same journal

Mature Schwann Cells Derived From Human Induced Pluripotent Stem Cells Promote Peripheral Nerve Regeneration In Vivo.

Neuroscience insights·2026
Same journal

Re-Examination and Extension of Manual Dexterity Behavioral Data in M1 Lesioned Adult Macaque Monkeys: A Survey of Therapies Induced Enhancement of Functional Recovery.

Neuroscience insights·2026
查看所有相关文章

相关实验视频

Updated: Jun 11, 2025

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex
07:42

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

Published on: August 17, 2018

11.7K

加巴,衰老和运动:功能和干预方面的考虑.

Tom S Novak1, Keith M McGregor2,3, Lisa C Krishnamurthy1,4,5

  • 1Emory University, Atlanta, GA, USA.

Neuroscience insights
|October 8, 2024
PubMed
概括
此摘要是机器生成的。

定期炼可以通过恢复大脑功能来帮助保持老年人的认知健康. 本综述探讨了运动如何影响GABAergic系统,对抑制过程至关重要,以支持大脑健康.

关键词:
胺黄油酸 (GABA) 是一种皮质阻断抑制是指皮质的抑制.磁共振光谱学 磁共振光谱学跨的磁性刺激

更多相关视频

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

14.2K
Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

17.4K

相关实验视频

Last Updated: Jun 11, 2025

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex
07:42

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

Published on: August 17, 2018

11.7K
Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

14.2K
Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

17.4K

科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 运动生理学 运动生理学

背景情况:

  • 老龄化人口面临认知能力下降和相关病理的风险增加.
  • 通过炼的心血管健康显示,在老年人中保持认知健康是有前途的.
  • 运动与改善大脑健康的联系机制,特别是神经递质的作用,需要进一步阐明.

研究的目的:

  • 审查衰老和运动对皮质抑制和GABAergic系统的相反影响.
  • 以突出评估GABAergic系统完整性的进展使用跨磁刺激 (TMS) 和磁共振光谱学 (MRS).
  • 讨论未来的研究方向,以了解衰老和运动中的GABAergic机制.

主要方法:

  • 审查现有的关于衰老,运动和大脑健康的文献.
  • 专注于体内测量,包括跨磁刺激 (TMS) 和磁共振光谱 (MRS).
  • 对研究研究胺黄油酸 (GABA) 系统的功能进行分析.

主要成果:

  • 衰老对皮质抑制和GABAergic系统功能产生负面影响.
  • 运动似乎可以抵消这些与年龄相关的衰退,可能通过恢复GABAergic过程.
  • 在TMS和MRS的进步为研究GABAergic完整性提供了增强的工具.

结论:

  • 了解衰老,运动和GABAergic系统之间的相互作用对于认知健康至关重要.
  • 运动可以通过积极影响GABA水平和功能来减轻与年龄相关的认知衰退.
  • 基于GABAergic机制的有针对性的干预措施可以改善老化中的大脑健康.