吸入的性高性双价盐可以减少耐火性慢性咳的频率
Hisham Abubakar-Waziri1, David A Edwards2,3,4, Deen Bhandu Bhatta4
1National Heart and Lung Institute, Imperial College London, and Royal Brompton and Harefield Hospital, London, UK.
ERJ open research
|October 8, 2024
概括
吸入的性高性双价盐 (性HDS) 通过滋呼吸道来治疗慢性咳具有前景. 在一项小型研究中,性HDS在pH9显著降低了咳频率.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 慢性咳是一种具有挑战性的疾病,需要有效治疗.
- 吸入的性高性双价盐 (性HDS) 被假设通过喉和气管水分来缓解耐火性慢性咳.
研究的目的:
- 通过鼻腔吸入进行的性HDS组合物 (SC001) 抑制咳的疗效.
- 为了比较SC001在pH8和pH9的效果与鼻腔盐液对照.
主要方法:
- 一项探索性,单盲,受控研究,涉及12名耐火慢性咳患者.
- 患者接受了鼻液作为对照和SC001 (pH8或pH9) 使用标准化鼻喷雾装置.
- 使用数字咳监测器连续监测咳频率,在三个为期1周的时间段 (基线,对照,积极治疗) 进行监测.
主要成果:
- 鼻腔吸入SC001证明了对照调整后的咳率降低,在pH 9 (降低高达35%) 与pH 8 (降低高达16%) 相比,在pH 9 (降低高达35%) 观察到更高的疗效.
- 每小时咳计数与视觉模拟分数之间的相关性在积极治疗期间显著改善.
- 在研究期间没有报告任何不良事件.
结论:
- 性HDS气溶,特别是pH值为9,对于患有耐火性慢性咳的患者来说是一个有前途的治疗选择.
- 需要对性HDS进行进一步的临床评估,以确认其疗效和安全性.
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