高流量加湿氧作为急性严重喘儿童的早期干预:一个可行性随机对照试验
Akshat Kapur1, Héctor Rojas-Anaya1,2,3, Graham Roberts4
1University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
ERJ open research
|October 8, 2024
概括
高流量加湿氧 (HiFlo) 可能是急性严重喘 (ASA) 的儿童对标准护理无反应的有希望的治疗方法. 一项可行性研究表明,HiFlo可以减少治疗升级和住院时间,这需要进一步研究.
科学领域:
- 儿科肺病学 儿科肺病学
- 紧急医疗 紧急医疗
- 临床试验 临床试验
背景情况:
- 在对初始支气管扩展剂无反应的儿童中治疗急性严重喘 (ASA) 存在挑战.
- 静脉注射药物具有不一致的疗效和常见的副作用.
- 高流量加湿氧 (HiFlo) 在呼吸条件中显示出潜力,但在ASA中缺乏证据.
研究的目的:
- 评估早期高流量加湿氧 (HiFlo) 干预急性严重喘 (ASA) 的儿童的可行性.
- 为了评估未来的最终随机对照试验的候选初级结果.
主要方法:
- 一个推迟同意的可行性随机对照试验在患有ASA的2-11岁儿童中进行.
- 在初始治疗后,儿童呼吸评估测量 (PRAM) 得分为5+的参与者被随机分配到HiFlo或标准护理.
- 候选初级结局包括需要升级的治疗失败和医院出院的时间标准.
主要成果:
- 尽管有COVID-19的干扰,但56名儿童被随机分配,同意率为89%.
- 在HiFlo组中,治疗失败发生在64%的患者中,而在标准治疗组中,失败率为86%.
- 与标准护理 (36.8小时) 相比,HiFlo手臂 (29.3小时) 的中位时间到出院标准较短.
结论:
- 早期的高流量加湿氧 (HiFlo) 似乎是对患有急性严重喘 (ASA) 的儿童的可行和潜在有益的干预措施.
- 确定的随机对照试验是有必要的,以确认HiFlo在这个人群中的有效性.
相关概念视频
Respiratory Assessment: Purpose and Indications
1.0K
Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
1.0K
Administering Oxygen by Mask
257
Administering Oxygen by Mask
Administering oxygen by mask is a common nursing intervention that provides supplemental oxygen to patients with respiratory distress or chronic lung conditions. This procedure involves delivering oxygen at a specified rate through a face mask connected to an oxygen source.
Equipment
The equipment necessary for this procedure includes:
Administering oxygen by mask is a common nursing intervention that provides supplemental oxygen to patients with respiratory distress or chronic lung conditions. This procedure involves delivering oxygen at a specified rate through a face mask connected to an oxygen source.
Equipment
The equipment necessary for this procedure includes:
257
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
180
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
180
Acute Respiratory Failure-V
124
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
124
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
388
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
388
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K


