相关实验视频
Updated: Jun 11, 2025

07:06
Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients
Published on: March 29, 2022
2.5K
年龄对高近视的人的水性幽默的影响
Kai Wen1, Mengjun Fu2, Yongtao Li1
1Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital.
Molecular vision
|October 8, 2024
概括
年龄显著影响高近视的水性蛋白. 这项研究揭示了与年龄相关的蛋白质变化,确定阿尔法-1抗素在老年高近视患者中受到上调,为视力丧失机制提供了洞察力.
科学领域:
- 眼科医生 眼科 眼科
- 蛋白质组学是指蛋白质组学.
- 分子生物学分子生物学
背景情况:
- 高近视是导致视力障碍的主要原因.
- 年龄是高近视发展的关键因素.
- 在高近视症中,年龄对水性蛋白的影响仍然未被描述.
研究的目的:
- 为了研究年龄对高近视的个体水性幽默蛋白质概况的影响.
- 在高近视患者的水性幽默中识别与年龄相关的差异表达蛋白 (DEPs).
主要方法:
- 从接受可植入膜透镜植入 (ICL) 的高近视患者中采集了水性幽默样本.
- 使用数据独立获取进行了蛋白质组分析,以确定DEP.
- 生物信息学分析 (KEGG,WGCNA) 和ELISA用于数据解释和验证.
主要成果:
- 18种蛋白质被上调,20种蛋白质被下调.
- 调节后的DEP在凝血和补充级联中得到丰富.
- 在老年高近视患者中,α-1-抗素显著上调,由ELISA证实.
结论:
- 这是第一个探索高近视期与年龄相关的水性幽默蛋白质变化的研究.
- 这些发现提供了关于高近视的年龄相关蛋白质组变化的全面数据集.
- 这项研究揭示了潜在的分子机制,这些机制是高近视进展和相关的眼损伤的基础.
相关概念视频
Open Angle Glaucoma: Treatment
403
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
403
Glaucoma: Overview
527
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
527
Focusing of Light in the Eye
2.5K
Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
2.5K
Angle Closure Glaucoma: Treatment
448
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
448
Photoreceptors and Visual Pathways
5.9K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
5.9K
Accessory Structures of the Eye
1.5K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.5K

