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评估功能作为通过皮肤进行冠状动脉干预的糖尿病患者不良结果的预测指标
Farima Sadat Mousavi1, Babak Bagheri1, Rozita Jalalian1
1Department of Cardiology, Faculty of Medicine, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Acta cardiologica
|October 8, 2024
概括
经过皮肤冠状动脉干预 (PCI) 的患有严重慢性病 (CKD) 的糖尿病患者面临着显著更高的死亡风险,主要不良心血管事件 (MACE) 和三重血管疾病 (TVD). 优化功能对于管理这些高风险患者至关重要.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 糖尿病学 糖尿病学
背景情况:
- 心血管疾病是导致死亡的首要原因,特别是在皮肤穿冠状动脉干预 (PCI) 后的糖尿病患者中.
- 慢性病 (CKD) 是这一群体的额外危险因素,但其对PCI后主要不良心血管事件 (MACE),死亡率和三重血管疾病 (TVD) 等结果的影响仍在争论中,特别是在2型糖尿病 (T2DM) 中.
研究的目的:
- 研究功能对接受PCI的糖尿病患者的MACE,死亡率和TVD的影响.
- 评估不同程度的CKD与PCI后心血管结果之间的关联.
主要方法:
- 对接受PCI的糖尿病患者的分析,根据膜过率 (GFR) 分层,以评估功能.
- 使用后勤回归和接收器运行特征 (ROC) 分析来确定关联和预测值.
主要成果:
- 严重的CKD与增加1个月死亡率 (OR: 15.694),1个月的MACE (OR: 7.734) 和TVD (OR: 3.740) 的几率显著相关.
- 患有严重CKD的患者也有更高的6个月死亡率 (OR:12.192) 和6个月MACE (OR:3.848) 的几率.
- 在1个月和6个月的随访期间,GFR显示出对死亡率的显著预测准确性 (AUC:分别为0.77和0.71).
结论:
- 功能障碍,特别是严重的CKD,在PCI后的糖尿病患者中显著增加了MACE,死亡率和TVD的风险.
- 实施优化功能和个性化心血管管理的策略对于改善这一脆弱患者群体的治疗结果至关重要.
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