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咖啡因对随后睡眠的剂量和时间影响:一项随机临床交叉试验
Carissa L Gardiner1,2, Jonathon Weakley1,2,3, Louise M Burke4
1School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, Australia.
Sleep
|October 8, 2024
概括
在睡前12小时内摄入400毫克咖啡因可以扰乱睡眠启动和结构. 在睡眠前4小时服用较低剂量 (100毫克) 对睡眠质量没有显著影响.
科学领域:
- 睡眠科学 睡眠科学
- 药理学 药理学是指药理学的学科.
- 人类生理学 人类生理学
背景情况:
- 咖啡因是一种广泛消费的兴奋剂,已知对警觉有影响.
- 了解咖啡因对睡眠时间和质量的影响对于公共健康至关重要.
- 之前的研究对咖啡因对睡眠的影响产生了不同的结果.
研究的目的:
- 为了确定典型 (100毫克) 和高 (400毫克) 咖啡因剂量对随后睡眠的影响.
- 为了研究咖啡因摄入时间 (早上,下午,晚上) 对睡眠的影响.
- 评估咖啡因摄入后的客观和主观睡眠质量指标.
主要方法:
- 随机,双盲,安慰剂控制的交叉试验.随机,双盲,安慰剂控制的交叉试验.
- 参与了23名健康的男性,通常摄入中等量的咖啡因.
- 在七种条件下,使用家庭部分多睡眠学和睡眠日记来监测睡眠.
主要成果:
- 100毫克咖啡因与安慰剂相比没有显著影响睡眠.
- 400毫克咖啡因在睡前12小时内摄入时,显著延迟睡眠开始和改变睡眠结构.
- 在睡前8小时内摄入400毫克咖啡因时,睡眠碎片化增加,在睡前4小时内摄入咖啡因时,感知到睡眠质量下降.
结论:
- 100毫克的咖啡因剂量通常在睡前4小时内是安全的.
- 如果在睡前12小时内摄入400毫克咖啡因,可能会对睡眠产生负面影响.
- 个人可能会低估咖啡因对睡眠质量的破坏性影响.
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