心脏移植后使用循环死亡后获得的器官进行心脏移植后的早期脏结果
Joyce C Zhou1, Meghan E Sise2, Kamila Drezek3
1Department of Medicine Massachusetts General Hospital Boston MA USA.
Journal of the American Heart Association
|October 8, 2024
概括
使用循环死亡 (DCD) 器官捐赠的心脏移植显示了与脑死亡 (DBD) 器官捐赠类似的短期脏结果. 在DDC接受者中,早期急性损伤 (AKI) 与持续的功能障碍有关.
科学领域:
- 心血管外科心血管外科
- 移植医学 移植医学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 循环死亡后 (DCD) 捐赠者的捐赠心脏在移植中的使用正在增加.
- 关于接受DCD心脏移植的接受者结局的数据有限.
研究的目的:
- 为了比较从DCD捐献者获得器官的心脏移植接受者与脑死亡 (DBD) 捐献者捐献器官的短期结局.
主要方法:
- 一项回顾性队列研究包括2016年4月至2022年8月期间的225名心脏移植接受者 (55名DCD).
- 评估的脏结局包括移植后1,4周和16周估计的球过率 (eGFR).
- 分析了急性损伤 (AKI) 的发生率和在第一周内需要替代疗法.
主要成果:
- 接受DCD心脏的人在移植后的第一周内显示出与DBD接受者相似的结局.
- 在DDD和DBD组中,AKI (47.3%对46.5%) 和代疗法 (3.6%对4.7%) 的发生率在DDD和DBD组之间是相似的.
- 患有早期AKI的DDC接受者在16周经历了持续性功能障碍,与没有早期AKI的患者不同.
结论:
- 循环死亡心脏移植后的捐赠与脑死亡后的捐赠相比,与类似的脏结果有关.
- 这些发现支持继续使用DCD器官进行心脏移植.
- 早期急性损伤是DCD和DBD心脏移植接受者持续性功能障碍的重要预测因素.
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