中年基线前列腺特异性抗原,速度和翻倍时间与致命的前列腺癌和死亡率相关
Giuseppe Ottone Cirulli1,2, Matthew Davis1, Alex Stephens3
1VUI Center for Outcomes Research, Analysis, and Evaluation, Henry Ford Health System, Detroit, Michigan, USA.
Cancer
|October 8, 2024
概括
中年基线前列腺特异性抗原 (MB PSA) 有效评估致命前列腺癌风险,类似于 PSA 翻倍时间 (PSADT) 和 PSA 速度 (PSAV). 这些发现表明MB PSA可能是增强前列腺癌查策略的实际工具.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 前列腺特异性抗原 (PSA) 查旨在早期检测前列腺癌.
- 中年基线PSA (MB PSA) 是风险分层的一个建议指标.
- PSA查的潜在危害需要精细的风险评估工具.
研究的目的:
- 为了比较MB PSA,PSA翻倍时间 (PSADT) 和PSA速度 (PSAV) 在预测致命前列腺癌 (PCa) 的有效性.
- 评估这些标志物在一个多样化的北美人口接受当代查.
主要方法:
- 分析了77,594名年龄在40-59岁的男性,他们至少进行了两次PSA测试,11634名男性至少进行了三次PSA测试.
- 使用细灰回归来评估MB PSA,PSADT,PSAV和致命PCa发展之间的关联.
- 采用时间依赖的ROC/AUC分析来比较5年,10年和15年的预测性表现.
主要成果:
- MB PSA和PSADT显示出与致命的PCa有显著的关联.
- 在具有足够数据用于PSAV计算的患者中,MB PSA和PSAV显示出显著的关联.
- 与MB PSA相比,PSADT和PSAV对于致命的PCa没有表现出优越的预测能力 (AUC).
结论:
- 中年基线PSA在评估患致命前列腺癌的风险方面与PSADT和PSAV同样有效.
- 这些发现表明MB PSA可能是优化前列腺癌查方案的有价值和实用的工具.
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