Jove
Visualize
联系我们

相关概念视频

Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Predicting human pharmacokinetic parameters of drugs using a multi-tissue chip platform integrating liver, kidney, and skeletal muscle microphysiological systems.

Lab on a chip·2026
Same author

A genetic algorithm for self-supervised models of oscillatory neurodynamics.

bioRxiv : the preprint server for biology·2025
Same author

Flexible resonance in prefrontal networks with strong feedback inhibition.

PLoS computational biology·2018
Same author

pVEC hydrophobic N-terminus is critical for antibacterial activity.

Journal of peptide science : an official publication of the European Peptide Society·2018
Same author

The effect of a beta-lactamase inhibitor peptide on bacterial membrane structure and integrity: a comparative study.

Journal of peptide science : an official publication of the European Peptide Society·2017
Same author

Hetereogeneity in Neuronal Intrinsic Properties: A Possible Mechanism for Hub-Like Properties of the Rat Anterior Cingulate Cortex during Network Activity.

eNeuro·2017
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jun 25, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

17.8K

基于途径的相似度测量以量化转录组学人类组织与临床前模型之间的相似性.

Paarth Parekh1, Jason Sherfey1, Begum Alaybeyoglu1

  • 1Javelin Biotech, Inc., Woburn, Massachusetts, USA.

Clinical pharmacology and therapeutics
|October 8, 2024
PubMed
概括

一个新的基于途径的相似度测量 (PBSM) 量化了临床前模型对人类组织的相关性. 这种方法通过改善模型选择和减少翻译差距来帮助药物开发.

科学领域:

  • 生物技术和生物医学工程 生物技术和生物医学工程
  • 翻译医学是一种翻译医学.
  • 基因组学和转录基因组学

背景情况:

  • 临床前研究的临床翻译面临着由于物种差异和异质性而面临的挑战.
  • 微生理系统 (MPS) 提供了人类生理学的改进回顾,但缺乏定量相似性评估.
  • 需要方法来评估临床前模型对特定使用环境 (CoU) 的相关性.

研究的目的:

  • 开发和验证一种定量方法,即基于途径的相似度测量 (PBSM),用于评估临床前模型与人类系统的相似性.
  • 利用RNA测序 (RNA-seq) 数据和途径信息来评估药物开发模型中的人类相关性.
  • 证明PBSM在选择和验证特定CoU的临床前模型中的实用性.

主要方法:

  • 开发基于路径的相似度测量 (PBSM),将RNA-seq数据与路径信息集成在一起.
  • 应用PBSM来评估临床前模型和人体组织 (肝脏和心脏) 之间的转录组相似性.
  • 评估PBSM支持CoU选择,分析基因组影响和区分模型类型的能力.

主要成果:

  • PBSM提供了一种定量方法,用于比较临床前模型和人体组织之间的转录学相似性.
  • 对肝脏和心脏组织进行了概念验证,使得模型选择和验证得到了改进.

更多相关视频

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

4.1K
Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.9K

相关实验视频

Last Updated: Jun 25, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

17.8K
High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

4.1K
Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.9K
  • PBSM成功支持CoU选择,评估基因组的影响,并区分体外和体内模型.

    • 结论:

    • 通过定量评估临床前模型与人类系统的相似性,PBSM显著减少了药物开发中的翻译差距.
    • 促进了知情的模型选择,并增强了对临床前模型特定环境应用的理解.
    • 为改善体外模型的生理相关性和推进治疗干预提供了基础.