Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

3.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
3.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

N- and O‑Prenylated Quinolones: Syntheses and <i>In Vitro</i> and <i>In Vivo</i> Antischistosomal Evaluation.

ACS medicinal chemistry letters·2026
Same author

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

<i>N</i>‑Myristoyltransferase Inhibitors as a Potential Starting Point for the Development of Antischistosomal Agents.

ACS medicinal chemistry letters·2026
Same author

Correction to "Novel Scaffold Unlocks Potent Cross-Peptidase and Cross-Species Inhibitors as Promising Antimalarial Agents".

Journal of medicinal chemistry·2026
Same author

Novel Scaffold Unlocks Potent Cross-Peptidase and Cross-Species Inhibitors as Promising Antimalarial Agents.

Journal of medicinal chemistry·2026
Same author

Multidisciplinary Preclinical Investigations on Ferrocenyl, Ruthenocenyl, and Benzyl Derivatives of Niridazole as New Drug Candidates against Schistosomiasis.

ChemMedChem·2025

相关实验视频

Updated: Jun 11, 2025

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments
07:50

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments

Published on: October 25, 2024

1.6K

具有抗胞体活性的中环凯托比斯拉克坦.

Rongguo Ren1, Derek A Leas1, Cécile Häberli2,3

  • 1College of Pharmacy, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 986125, United States.

Journal of medicinal chemistry
|October 8, 2024
PubMed
概括

研究人员确定了新型的中环基托双乳作为一种有前途的新型抗阴囊体药物. 关键的结构特征对于对抗Schistosoma mansoni的活性至关重要,两种化合物显示出高疗效.

更多相关视频

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

11.8K
Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
09:10

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth

Published on: January 7, 2022

2.3K

相关实验视频

Last Updated: Jun 11, 2025

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments
07:50

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments

Published on: October 25, 2024

1.6K
Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

11.8K
Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
09:10

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth

Published on: January 7, 2022

2.3K

科学领域:

  • 药用化学 医学化学
  • 寄生虫学的寄生虫学
  • 药物发现 药物发现 药物发现

背景情况:

  • 杆菌仍然是一个重大的全球健康负担,需要开发新的治疗药物.
  • 现有治疗方法面临挑战,包括耐药性和副作用,推动寻找新型化学型的研究.
  • 抗胞体药物发现需要识别具有强效活性和有利的药物动力学特征的化合物.

研究的目的:

  • 发现和表征一种新型的抗胞体化合物.
  • 为了研究中环基托双酸盐对 Schistosoma mansoni 的结构-活性关系.
  • 评估这些新型化合物的物理化学特性和细胞毒性.

主要方法:

  • 合成和化学表征中环基托双乳酸盐.
  • 在体外查对 Schistosoma mansoni. 的检测.
  • 物理化学性质的评估,包括LogD7.4和水溶性.
  • 使用相关细胞系进行细胞毒性评估.

主要成果:

  • 中环基托双乳被确定为一种新的抗胞体化学型.
  • 子功能组和异印罗林子子结构对于抗胞体活性至关重要.
  • 化合物表现出有利的物理化学特性:LogD7.4 (<0至2.4) 和动力水溶性 (40至>320μM).
  • 观察到低细胞毒性 (IC50s:52至>390μM),两种化合物表现出强烈的活性 (IC50<5μM) 对活体S. mansoni.

结论:

  • 中环基托双乳代表了一种有前途的新化学支架,用于抗胞体药物开发.
  • 优化基替代是维持化学稳定性和增强抗胞体疗效的关键.
  • 鉴定到的化合物具有强度,可溶性和低毒性的良好平衡,需要进一步调查.